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Combining NMN and NR creates a potent approach to increase NAD+ levels. These longevity supplements work through separate mechanisms - NMN via direct cellular uptake and NR through NRK1 NRK2 enzymes. This NMN NR combination optimizes mitochondrial function, longevity enhancement products (https://wiki.e-o3.com:443/index.php?title=User:JeanettDunningha) pathways, and DNA repair more effectively than either compound alone.